Ketamine is approved as an established anaesthetic and pain medication and is prescription-only. It is not regulated by the German Narcotics Act (Betäubungsmittelgesetz). It may only be administered by physicians. For treatment in our practice, the so-called “off-label-use” is applied: a medical doctor is allowed to use a drug outside of the specific approval framework if there is an indication or medical justification for it. This justification exists in Augmented Psychotherapy with ketamine.