We see the use of ketamine as an addition (augmentation) to an established course of psychotherapy. The use of medication in Augmented Psychotherapy thus differs significantly from the classic psychopharmacological approach, which focuses more on the neurobiological antidepressant effect. We see the therapeutic potential of ketamine not only in its direct antidepressant effects, but also, among other things, in its mind-altering effects. These altered states of consciousness often make it possible to take a different perspective on oneself and one’s environment. Working with unconscious content and recognizing and breaking old patterns is more often possible. This can enormously enrich and intensify a psychotherapeutic process.